When running Chrome, there are some additional useful command line arguments.

As with most products, you can use a different binary with --binary, e.g., to run Chrome Dev on Linux:

./wpt run --binary `which google-chrome-unstable` chrome

Extra arguments to Chrome can be passed with --binary-args.

To enable all experimental web platform features (chrome://flags/#enable-experimental-web-platform-features):

./wpt run --binary-arg=--enable-experimental-web-platform-features chrome fullscreen/

To enable a specific runtime enabled feature:

./wpt run --binary-arg=--enable-blink-features=AsyncClipboard chrome clipboard-apis/

To bypass device selection and use mock media for tests using getUserMedia:

./wpt run --binary-arg=--use-fake-ui-for-media-stream --binary-arg=--use-fake-device-for-media-stream chrome mediacapture-streams/

Note: there’s an open issue for doing this using WebDriver.

Some of the above are most useful in combination, e.g., to run all tests in Chrome Dev with experimental web platform features enabled:

./wpt run --binary `which google-chrome-unstable` --binary-arg=--enable-experimental-web-platform-features chrome